Acephate

CASRN 30560-19-1

Notice - This site contains archived material

  • Status: The IRIS Assessment for the pesticide Acephate has been archived and is not being reassessed by IRIS at this time.
  • Archived IRIS Summary (PDF) (13 pp, 114 K)
  • Archive Disclaimer: The IRIS Program has archived a number of IRIS entries for pesticides that have been assessed more recently by EPA's Pesticide Program. The IRIS program announced in 2004 that chemicals that are solely used as pesticides would not be re-assessed.

Information from EPA's Pesticide Program


Additional toxicity information is available from EPA's Pesticide Program, including the following:

Health Hazard Assessments for Effects Other than Cancer


This data is archived and for historical reference only. Please refer to the Pesticide Program Toxicity Value.

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 114 K) archived on: 07/15/2016

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
4 x10-3 Nervous Inhibition of brain ChE LEL : 1.2 x10-1
mg/kg-day
30 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 114 K) archived on: 07/15/2016
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (13 pp, 114 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 114 K)

Oral Slope Factor: 8.7 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.5 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver adenomas and carcinomas (Chevron Chemical, 1982a)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 114 K)

Not Assessed under the IRIS Program.

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.