IRIS

Acephate

CASRN 30560-19-1

Notice - This webpage has been Archived

Archive Disclaimer - This site contains archived material.
This web page has been archived and is maintained for reference purposes only. Persons with disabilities having difficulty assessing archived materials may contact the IRIS Hotline for assistance. Please use the contact us form if you need immediate assistance.

This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 114 K) archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 4 x 10-3 Inhibition of brain ChE LEL : 1.2 x 10-1
mg/kg-day
30 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 114 K) archived on: 07/15/2016
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 114 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 114 K)

Oral Slope Factor: 8.7 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.5 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver adenomas and carcinomas (Chevron Chemical, 1982a)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 114 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites, including the following:
  • Human Health Benchmarks for Pesticides (HHBP) information. The HHBP website provides toxicity reference values for a number of pesticides to help determine if there is a potential health risk when pesticides are detected in water. However, the toxicity information from the HHBP table may be useful for other purposes.
  • EPA Pesticide Program toxicity information. This link provides information from EPA's Pesticide Program on the derivation of toxicity reference values.
  • EPA's Chemistry Dashboard. This link provides information from EPA's National Center for Computational Toxicology (NCCT) on chemical structures, experimental and predicted physicochemical and toxicity data, and additional links to relevant websites and applications.
  • Contact us about pesticides

You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.