2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)
CASRN 1163-19-5
- Toxicological Review (PDF) (126 pp, 820 K)
- IRIS Summary (PDF) (25 pp, 232 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (25 pp, 232 K)
last updated: 06/30/2008
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 7 x 10-3 | Neurobehavioral effects |
NOAEL
: 2.22 mg/kg-day |
300 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (25 pp, 232 K)
last updated: 06/30/2008
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF) (25 pp, 232 K)
last updated: 06/30/2008
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Suggestive evidence of carcinogenic potential | Guidelines for Carcinogen Risk Assessment (US EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for decabromodiphenyl ether provides suggestive evidence of carcinogenic potential.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (25 pp, 232 K)
Oral Slope Factor:
7 x10 -4 per mg/kg-day
Drinking Water Unit Risk:
2 x10 -8 per µg/L
Extrapolation Method:
Multistage model with linear extrapolation from the point of departure (LED12).
Tumor site(s): Hepatic
Tumor type(s): Liver neoplastic nodules or carcinoma (combined) (NTP (1986))
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (25 pp, 232 K)
Not Assessed under the IRIS Program.
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