2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)

CASRN 1163-19-5

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (25 pp, 232 K) last updated: 06/30/2008

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
7 x10-3 Nervous Neurobehavioral effects NOAEL : 2.22
mg/kg-day
300 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (25 pp, 232 K) last updated: 06/30/2008
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (25 pp, 232 K) last updated: 06/30/2008

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for decabromodiphenyl ether provides suggestive evidence of carcinogenic potential.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (25 pp, 232 K)

Oral Slope Factor: 7 x10 -4 per mg/kg-day
Drinking Water Unit Risk: 2 x10 -8 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (LED12).
Tumor site(s): Hepatic
Tumor type(s): Liver neoplastic nodules or carcinoma (combined) (NTP (1986))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (25 pp, 232 K)

Not Assessed under the IRIS Program.

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