Tributyltin oxide (TBTO)
CASRN 56-35-9 | DTXSID9020166
- IRIS Summary (PDF) (33 pp, 205 K)
- Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 205 K)
Last Updated: 09/01/1997
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Immune | 3 x 10-4 | Immunosuppression |
BMD10
: 3 x 10-2 mg/kg-day |
100 | High |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 205 K)
Last Updated: 09/01/1997
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF) (33 pp, 205 K)
Last Updated: 09/01/1997
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
| Carcinogenic potential cannot be determined | Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996) |
- There are no data in humans concerning development of cancer following exposure to tributyltin oxide (TBTO). Cancer bioassays following oral exposure have been conducted in rats and mice. Because of the questionable data from the bioassay in rats, EPA assigns TBTO to the "cannot be determined" category [U.S. EPA, 1996 (proposed)].
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 205 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 205 K)
Not assessed under the IRIS Program.
Additional EPA toxicity information may be available by visiting the following sites:
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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Critical Effect Systems
Chemical Structure for
Tributyltin oxide (TBTO)
