IRIS

p,p'-Dichlorodiphenyl dichloroethane (DDD)

CASRN 72-54-8

  • IRIS Summary (PDF) (9 pp, 97 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (9 pp, 97 K)
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (9 pp, 97 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (9 pp, 97 K) Last Updated: 08/22/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on an increased incidence of lung tumors in male and female mice, liver tumors in male mice and thyroid tumors in male rats. DDD is structurally similar to, and is a known metabolite of DDT, a probable human carcinogen.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (9 pp, 97 K)

Oral Slope Factor: 2.4 x 10 -1 per mg/kg-day
Drinking Water Unit Risk: 6.9 x 10 -6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver tumors (Tomatis et al., 1974)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (9 pp, 97 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

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