IRIS

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

CASRN 121-82-4

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (7 pp, 896 K) last updated: 08/30/2018

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 4 x 10-3 Convulsions in F344 rats BMDL05 (HED): 1.3
mg/kg-day
300 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (7 pp, 896 K) last updated: 08/30/2018
Information reviewed but value not estimated.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (7 pp, 896 K) last updated: 08/30/2018

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is suggestive evidence of carcinogenic potential for RDX based on evidence of benign and malignant tumors in the liver and lungs of B6C3F1 mice or F344 rats.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (7 pp, 896 K)

Oral Slope Factor: 8 x 10 -2 per mg/kg-day
Extrapolation Method: Linear extrapolation from the POD (BMDL10-HED) associated with a 10% extra cancer risk
Tumor site(s): Hepatic, Respiratory
Tumor type(s): Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) (Lish et al., 1984)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (7 pp, 896 K)

Information reviewed but value not estimated.

Organ/System-Specific RfDs

System RfD (mg/kg-day) Basis POD UF Confidence
Nervous 4 x 10-3 Convulsions in F344 rats BMDL05 (HED): 1.3
mg/kg-day
300 Medium
Urinary 1 x 10-2 Kidney medullary papillary necrosis in F344 rats NOAEL (HED): 3.9
mg/kg-day
300 Medium
Reproductive 8 x 10-4 Suppurative prostatitis in F344 rats BMDL10 (HED): 2.3 x 10-1
mg/kg-day
300 Low

 


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