Cumene

CASRN 98-82-8

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 155 K) last updated: 08/01/1997

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1 x 10-1 Urinary Increased average kidney weight in female rats NOAEL : 1.10 x 102
mg/kg-day
1000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 155 K) last updated: 08/01/1997

RfC (mg/m3) System Basis PoD Composite UF Confidence
4 x 10-1 Endocrine, Urinary Increased kidney weights in female rats and adrenal weights in male and female rats NOAEL (HEC): 4.35 x 102
mg/m3
1000 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (22 pp, 155 K) last updated: 08/01/1997

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Carcinogenic potential cannot be determined Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Under the proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), it is concluded that the carcinogenic potential of cumene cannot be determined because no adequate data, such as well-conducted long-term animal studies or reliable human epidemiological studies, are available for any assessment.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 155 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 155 K)

Not assessed under the IRIS Program.

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