Acetaldehyde

CASRN 75-07-0

  • IRIS Summary (PDF) (20 pp, 147 K)
  • Status: Acetaldehyde is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (20 pp, 147 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (20 pp, 147 K) last updated: 10/01/1991

RfC (mg/m3) System Basis PoD Composite UF Confidence
9 x10-3 Nervous, Respiratory Degeneration of olfactory epithelium NOAEL (HEC): 8.7
mg/m3
1000 Low

Cancer Assessment


Weight of Evidence for Cancer (PDF) (20 pp, 147 K) last updated: 06/30/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on increased incidence of nasal tumors in male and female rats and laryngeal tumors in male and female hamsters after inhalation exposure.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (20 pp, 147 K)

Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (20 pp, 147 K)

Inhalation Unit Risk: 2.2 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage-variable exposure input form (extra risk)
Tumor site(s): Respiratory
Tumor type(s): Nasal squamous cell carcinoma or adenocarcinoma (Woutersen and Appleman, 1984)


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