Nickel subsulfide

CASRN 12035-72-2

  • IRIS Summary (PDF) (11 pp, 109 K)
  • Status: Nickel subsulfide is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (11 pp, 109 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (11 pp, 109 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (11 pp, 109 K) last updated: 09/30/1987

WOE Characterization Framework for WOE Characterization
A (Human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Increased risks of lung and nasal cancer in humans exposed to nickel refinery dust, most of which was believed to have been nickel subsulfide; increased tumor incidences in animals by several routes of administration in several animal species and strains; and positive results in genotoxicity assays form the basis for this classification.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 109 K)

Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (11 pp, 109 K)

Inhalation Unit Risk: 4.8 x10 -4 per µg/m3
Extrapolation Method: Additive and multiplicative
Tumor site(s): Respiratory
Tumor type(s): Lung cancer (Enterline and Marsh, 1982; Chovil et al., 1981; Peto et al., 1984; Magnus et al., 1982)


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