IRIS

Nickel refinery dust

CASRN NA

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 104 K)
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 104 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (10 pp, 104 K) last updated: 09/30/1987

WOE Characterization Framework for WOE Characterization
A (Human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Human data in which exposure to nickel refinery dust caused lung and nasal tumors in sulfide nickel matte refinery workers in several epidemiologic studies in different countries, and on animal data in which carcinomas were produced in rats by inhalation and injection.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 104 K)

Not Assessed under the IRIS Program.


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 104 K)

Inhalation Unit Risk: 2.4 x10 -4 per µg/m3
Extrapolation Method: Additive and multiplicative
Tumor site(s): Respiratory
Tumor type(s): Lung cancer (Enterline and Marsh, 1982; Chovil et al., 1981; Peto et al., 1984; Magnus et al., 1982)


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