IRIS

Xylenes

CASRN 1330-20-7

Health Hazard Assessments for Effects Other than Cancer

Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 203 K) last updated: 02/21/2003

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Other 2 x 10-1 Decreased body weight, increased mortality NOAEL : 1.79 x 102
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 203 K) last updated: 02/21/2003

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 1 x 10-1 Impaired motor coordination (decreased rotarod performance) NOAEL (HEC): 39
mg/m3
300 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (33 pp, 203 K) last updated: 02/21/2003

WOE Characterization Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Basis:
  • Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), data are inadequate for an assessment of the carcinogenic potential of xylenes. Adequate human data on the carcinogenicity of xylenes are not available, and the available animal data are inconclusive as to the ability of xylenes to cause a carcinogenic response. Evaluations of the genotoxic effects of xylenes have consistently given negative results.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 203 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 203 K)

Not assessed under the IRIS Program.

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