CASRN 1582-09-8

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) last updated: 07/01/1989

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Hematologic 7.5 x 10-3 Increased liver weights; increase in methemoglobin NOEL : 7.5 x 10-1
100 High


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K)
Not assessed under the IRIS Program.


Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) last updated: 08/22/1988

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
  • Classification is based on the induction of urinary tract tumors (renal pelvis carcinomas and urinary bladder papillomas) and thyroid tumors (adenomas/carcinomas combined) in one animal species (F344 rats) in one study. Trifluralin is structurally similar to ethalfluralin, a carcinogen in the rat.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 7.7 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.2 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Urinary, Endocrine
Tumor type(s): Combined renal pelvis carcinomas, urinary bladder papillomas and/or thyroid adenomas and carcinomas (Emmerson et al., 1980)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites, including the following:
  • Human Health Benchmarks for Pesticides (HHBP) information. The HHBP website provides toxicity reference values for a number of pesticides to help determine if there is a potential health risk when pesticides are detected in water. However, the toxicity information from the HHBP table may be useful for other purposes.
  • EPA Pesticide Program toxicity information. This link provides information from EPA's Pesticide Program on the derivation of toxicity reference values.
  • EPA's Chemistry Dashboard. This link provides information from EPA's National Center for Computational Toxicology (NCCT) on chemical structures, experimental and predicted physicochemical and toxicity data, and additional links to relevant websites and applications.
  • Contact us about pesticides

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