1,1,1,2-Tetrachloroethane

CASRN 630-20-6

  • IRIS Summary (PDF) (13 pp, 117 K)
  • Status: 1,1,1,2-Tetrachloroethane is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 117 K) last updated: 09/30/1987

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
3 x10-2 Hepatic, Urinary Mineralization of the kidneys in males, hepatic clear cell change in females LOAEL : 8.93 x101
mg/kg-day
3000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 117 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (13 pp, 117 K) last updated: 03/01/1989

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Increased incidence of combined hepatocellular adenomas and carcinomas in female mice; inadequate evidence from human studies.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 117 K)

Oral Slope Factor: 2.6 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 7.4 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma or carcinoma (NTP, 1983)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 117 K)

Inhalation Unit Risk: 7.4 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma or carcinoma (NTP, 1983)


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