IRIS

Folpet

CASRN 133-07-3

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This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Other 1 x 10-1 Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels) NOEL : 1.0 x 101
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) archived on: 07/15/2016
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 3.5 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 1.0 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Digestive tract tumors (adenoma and/ or adenocarcinoma) (Chevron, 1982)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Not Assessed under the IRIS Program.

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