CASRN 133-07-3

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Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Other 1 x 10-1 Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels) NOEL : 1.0 x 101
100 High


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) archived on: 07/15/2016
Not assessed under the IRIS Program.


Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
  • Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 3.5 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 1.0 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Digestive tract tumors (adenoma and/ or adenocarcinoma) (Chevron, 1982)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites, including the following:
  • Human Health Benchmarks for Pesticides (HHBP) information. The HHBP website provides toxicity reference values for a number of pesticides to help determine if there is a potential health risk when pesticides are detected in water. However, the toxicity information from the HHBP table may be useful for other purposes.
  • EPA Pesticide Program toxicity information. This link provides information from EPA's Pesticide Program on the derivation of toxicity reference values.
  • EPA's Chemistry Dashboard. This link provides information from EPA's National Center for Computational Toxicology (NCCT) on chemical structures, experimental and predicted physicochemical and toxicity data, and additional links to relevant websites and applications.
  • Contact us about pesticides

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