Notice - This site contains archived material
- Status: The IRIS Assessment for the pesticide Folpet has been archived and is not being reassessed by IRIS at this time.
- Archived IRIS Summary (PDF) (13 pp, 115 K)
- Archive Disclaimer: The IRIS Program has archived a number of IRIS entries for pesticides that have been assessed more recently by EPA's Pesticide Program. The IRIS program announced in 2004 that chemicals that are solely used as pesticides would not be re-assessed.
Information from EPA's Pesticide Program
- Human Health Benchmarks for Pesticides (HHBP) information for Folpet. The HHBP website provides toxicity reference values for a number of pesticides to help determine if there is a potential health risk when pesticides are detected in water. However, the toxicity information from the HHBP table may be useful for other purposes.
- EPA Pesticide Program toxicity information for Folpet. This link provides information from EPA's Pesticide Program on the derivation of toxicity reference values.
- Additional information from EPA's Pesticide Program for Folpet.
- Contact us about pesticides
This data is archived and for historical reference only. Please refer to the Pesticide Program Toxicity Value.
Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K)
archived on: 07/15/2016
|System||RfD (mg/kg-day)||Basis||PoD||Composite UF||Confidence|
|Hepatic, Other||1 x 10-1||Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels)||
: 1.0 x 101
Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K)
Not assessed under the IRIS Program.
Weight of Evidence for Cancer (PDF) (13 pp, 115 K)
archived on: 07/15/2016
|WOE Characterization||Framework for WOE Characterization|
|B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)||Guidelines for Carcinogen Risk Assessment (US EPA, 1986)|
- Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
- This may be a synopsis of the full weight-of-evidence narrative.
Oral Slope Factor:
3.5 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 1.0 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Digestive tract tumors (adenoma and/ or adenocarcinoma) (Chevron, 1982)
Not Assessed under the IRIS Program.
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