Dieldrin

CASRN 60-57-1

  • IRIS Summary (PDF) (18 pp, 135 K)
  • Status: Dieldrin is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (18 pp, 135 K) last updated: 09/07/1988

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
5 x10-5 Hepatic Liver lesions NOAEL : 5 x10-3
mg/kg-day
100 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (18 pp, 135 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (18 pp, 135 K) last updated: 09/07/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Dieldrin is carcinogenic in seven strains of mice when administered orally. Dieldrin is structurally related to compounds (aldrin, chlordane, heptachlor, heptachlor epoxide, and chlorendic acid) which produce tumors in rodents.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (18 pp, 135 K)

Oral Slope Factor: 1.6 x10 1 per mg/kg-day
Drinking Water Unit Risk: 4.6 x10 -4 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver carcinoma (Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (18 pp, 135 K)

Inhalation Unit Risk: 4.6 x10 -3 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver carcinoma (Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983)


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