1,3-Dichloropropene

CASRN 542-75-6

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 213 K) last updated: 05/25/2000

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
3 x10-2 Gastrointestinal Chronic irritation BMDL10 : 3.4
mg/kg-day
100 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 213 K) last updated: 05/25/2000

RfC (mg/m3) System Basis PoD Composite UF Confidence
2 x10-2 Respiratory Hypertrophy/ hyperplasia of the nasal respiratory epithelium BMCL10 (HEC): 7.2 x10-1
mg/m3
30 High

Cancer Assessment


Weight of Evidence for Cancer (PDF) (34 pp, 213 K) last updated: 05/25/2000

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Known/likely human carcinogen Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Although the available human data are inadequate, 1,3-dichloropropene is characterized as "likely" to be a human carcinogen in accordance with the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 213 K)

Oral Slope Factor: 1 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 3 x10 -6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Urinary
Tumor type(s): Urinary bladder carcinoma (NTP, 1985)


Oral Slope Factor: 5 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 2 x10 -6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma/carcinoma (NTP, 1985)


Oral Slope Factor: 5 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1 x10 -6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma/carcinoma (Stott et al., 1995)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 213 K)

Inhalation Unit Risk: 4 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Respiratory
Tumor type(s): Bronchioalveolar adenoma (Lomax et al., 1989)


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