Bromoform

CASRN 75-25-2

  • IRIS Summary (PDF) (23 pp, 152 K)
  • Status: Bromoform is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 152 K) last updated: 09/30/1987

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
2 x 10-2 Hepatic Hepatic lesions NOEL : 1.79 x 101
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 152 K) last updated: 12/01/1993
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (23 pp, 152 K) last updated: 09/01/1990

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on inadequate human data and sufficient evidence of carcinogenicity in animals, namely an increased incidence of tumors after oral administration of bromoform in rats and intraperitoneal administration in mice. Bromoform is genotoxic in several assay systems. Also, bromoform is structurally related to other trihalomethanes (e.g., chloroform, bromodichloromethane, dibromochloromethane) which have been verified as either probable or possible carcinogens.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 152 K)

Oral Slope Factor: 7.9 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.3 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Neoplastic lesions in the large intestine (NTP, 1988)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 152 K)

Inhalation Unit Risk: 1.1 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Neoplastic lesions in the large intestine (NTP, 1988)


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