Acetonitrile

CASRN 75-05-8

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) last updated: 03/03/1999
Information reviewed but value not estimated.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 165 K) last updated: 03/03/1999

RfC (mg/m3) System Basis PoD Composite UF Confidence
6 x10-2 Other Mortality NOAEL (HEC): 6.0 x101
mg/m3
100
MF: 10
Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (23 pp, 165 K) last updated: 03/03/1999

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Carcinogenic potential cannot be determined Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Under the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the carcinogenic potential of ACN following inhalation, oral, or dermal exposure is best characterized as "cannot be determined because the existing evidence is composed of conflicting data (e.g., some evidence is suggestive of carcinogenic effects, but other equally pertinent evidence does not confirm any concern)."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

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