Carbon tetrachloride

CASRN 56-23-5

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (20 pp, 363 K) last updated: 03/31/2010

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
4 x10-3 Hepatic Elevated serum SDH activity BMD2x (ADJ): 3.9
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (20 pp, 363 K) last updated: 03/31/2010

RfC (mg/m3) System Basis PoD Composite UF Confidence
1 x10-1 Hepatic Fatty changes in the liver BMCL10 (HEC): 14.3
mg/m3
100 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (20 pp, 363 K) last updated: 03/31/2010

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), carbon tetrachloride is "likely to be carcinogenic to humans."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (20 pp, 363 K)

Oral Slope Factor: 7 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 2 x10 -6 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma or carcinoma (Nagano et al., 2007b, JBRC, 1998)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (20 pp, 363 K)

Inhalation Unit Risk: 6 x10 -6 per µg/m3
Extrapolation Method: Log-probit model with linear extrapolation from the POD (LEC10).
Tumor site(s): Endocrine
Tumor type(s): Pheochromocytoma (Nagano et al. 2007b, JBRC 1998)


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