1,1,2-Trichloroethane

CASRN 79-00-5

  • IRIS Summary (PDF) (13 pp, 115 K)
  • Status: 1,1,2-Trichloroethane is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) last updated: 09/26/1988

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
4 x10-3 Immune, Hematologic Clinical serum chemistry (effects on erythrocytes and depressed humoral immune status) NOAEL : 3.9
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (13 pp, 115 K) last updated: 03/31/1987

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Hepatocellular carcinomas and pheochromocytomas in one strain of mice forms the basis for this classification. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 5.7 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 1.6 x10 -6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (NCI, 1978)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Inhalation Unit Risk: 1.6 x10 -5 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (NCI, 1978)


You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.