IRIS

Methyl isobutyl ketone (MIBK)

CASRN 108-10-1

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 162 K) last updated: 04/25/2003
Information reviewed but value not estimated.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 162 K) last updated: 04/25/2003

System RfC (mg/m3) Basis PoD Composite UF Confidence
Developmental, Musculoskeletal 3 Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats. NOAEL (HEC): 1026
mg/m3
300 Low/Medium
Developmental, Musculoskeletal 3 Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats. NOAEL (HEC): 1026
mg/m3
300 Low/Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (23 pp, 162 K) last updated: 04/25/2003

WOE Characterization Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (US EPA, 1999)
Basis:
  • Under the draft revised cancer guidelines (U.S. EPA, 1999), the data for MIBK are inadequate for an assessment of human carcinogenic potential. No data were located regarding the existence of an association between cancer and MIBK exposure in humans, but studies of the in vivo and in vitro genotoxicity of MIBK overwhelmingly provided negative responses.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 162 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 162 K)

Not assessed under the IRIS Program.

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