Bromomethane

CASRN 74-83-9

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (29 pp, 184 K) last updated: 09/26/1988

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1.4 x10-3 Gastrointestinal Epithelial hyperplasia of the forestomach NOAEL : 1.4
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (29 pp, 184 K) last updated: 04/01/1992

RfC (mg/m3) System Basis PoD Composite UF Confidence
5 x10-3 Nervous, Respiratory Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity LOAEL (HEC): 4.8 x10-1
mg/m3
100 High

Cancer Assessment


Weight of Evidence for Cancer (PDF) (29 pp, 184 K) last updated: 06/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Inadequate human and animal data: a single mortality study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power. Bromomethane has shown genotoxicity.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (29 pp, 184 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (29 pp, 184 K)

Not assessed under the IRIS Program.

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