IRIS

Di (2-ethylhexyl)phthalate (DEHP)

CASRN 117-81-7

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 121 K) last updated: 01/31/1987

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic 2 x 10-2 Increased relative liver weight LOAEL : 1.9 x 101
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 121 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (14 pp, 121 K) last updated: 09/07/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 121 K)

Oral Slope Factor: 1.4 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 4 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma and adenoma (NTP, 1982)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 121 K)

Not Assessed under the IRIS Program.

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