Di (2-ethylhexyl)phthalate (DEHP)
- IRIS Summary (PDF) (14 pp, 121 K)
Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 121 K)
last updated: 01/31/1987
|System||RfD (mg/kg-day)||Basis||PoD||Composite UF||Confidence|
|Hepatic||2 x 10-2||Increased relative liver weight||
: 1.9 x 101
Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 121 K)
Not assessed under the IRIS Program.
Weight of Evidence for Cancer (PDF) (14 pp, 121 K)
last updated: 09/07/1988
|WOE Characterization||Framework for WOE Characterization|
|B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)||Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)|
- Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes.
- This may be a synopsis of the full weight-of-evidence narrative.
Oral Slope Factor:
1.4 x 10 -2 per mg/kg-day
Drinking Water Unit Risk: 4 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma and adenoma (NTP, 1982)
Not Assessed under the IRIS Program.
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