Biphenyl

CASRN 92-52-4

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 111 K) last updated: 08/27/2013

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
5 x10-1 Urinary Renal papillary mineralization in male F344 rats BMDL10 (HED99): 13.9
mg/kg-day
30
MF: 10
Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 111 K) last updated: 08/27/2013
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (12 pp, 111 K) last updated: 08/27/2013

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for biphenyl provides “suggestive evidence of carcinogenic potential” based on increased incidence of urinary bladder tumors (transitional cell papillomas and carcinomas) in male F344 rats (Umeda et al., 2002) and liver tumors (hepatocellular adenomas and carcinomas) in female BDF1 mice (Umeda et al., 2005) exposed to biphenyl in the diet for 104 weeks, as well as information on mode of carcinogenic action. The carcinogenic potential of biphenyl in humans has not been investigated.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 111 K)

Oral Slope Factor: 8 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.3 x10 -7 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Liver adenomas or carcinomas (Umeda et al., 2005)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 111 K)

Information reviewed but value not estimated.

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