2,4,6-Trichlorophenol

CASRN 88-06-2

  • IRIS Summary (PDF) (13 pp, 115 K)
  • Status: 2,4,6-Trichlorophenol is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K)
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) last updated: 07/01/1991
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (13 pp, 115 K) last updated: 06/01/1990

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemias in male rats and hepatocellular adenomas or carcinomas in male and female mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 1.1 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 3.1 x10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Inhalation Unit Risk: 3.1 x10 -6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)


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