1,2,4-Trichlorobenzene

CASRN 120-82-1

  • IRIS Summary (PDF) (14 pp, 118 K)
  • Status: 1,2,4-Trichlorobenzene is not being reassessed by IRIS at this time.

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 118 K) last updated: 05/01/1992

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1 x10-2 Endocrine Increased adrenal weights; vacuolization of zona fasciculata in the cortex NOAEL : 1.48 x101
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (14 pp, 118 K) last updated: 06/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K)

Not assessed under the IRIS Program.

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