Toluene

CASRN 108-88-3

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (35 pp, 230 K) last updated: 09/23/2005

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
8 x10-2 Urinary Increased kidney weight BMDL : 238
mg/kg-day
3000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (35 pp, 230 K) last updated: 09/23/2005

RfC (mg/m3) System Basis PoD Composite UF Confidence
5 Nervous Neurological effects in occupationally-exposed workers NOAEL (ADJ): 46
mg/m3
10 High

Cancer Assessment


Weight of Evidence for Cancer (PDF) (35 pp, 230 K) last updated: 09/23/2005

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess the carcinogenic potential of toluene because studies of humans chronically exposed to toluene are inconclusive, toluene was not carcinogenic in adequate inhalation cancer bioassays of rats and mice exposed for life (CIIT, 1980 NTP, 1990 Huff, 2003), and increased incidences of mammary cancer and leukemia were reported in a lifetime rat oral bioassay at a dose level of 500 mg/kg-day but not at 800 mg/kg-day (Maltoni et al., 1997).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (35 pp, 230 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (35 pp, 230 K)

Not assessed under the IRIS Program.

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