1,3,5-Trimethylbenzene

CASRN 108-67-8

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 323 K) last updated: 09/09/2016

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
1 x10-2 Nervous Decreased pain sensitivity in male Wistar rats BMDL1SD (HED): 3.5
mg/kg-day
300 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 323 K) last updated: 09/09/2016

RfC (mg/m3) System Basis POD Composite UF Confidence
6 x 10-2 Nervous Decreased pain sensitivity in male Wistar rats BMDL1SD(HEC): 18.15 mg/m3 300 Low/Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (10 pp, 323 K) last updated: 09/09/2016

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA 2005), there is “inadequate information to assess carcinogenic potential” of TMBs. This characterization is based on the fact that there is no information regarding the carcinogenicity of TMBs in humans and that the only animal study available on the carcinogenicity of 1,2,4‑TMB observed no statistically significant carcinogenic effects. No studies regarding the carcinogenicity of 1,2,3‑TMB or 1,3,5‑TMB were identified in the available scientific literature.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 323 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 323 K)

Not assessed under the IRIS Program.

Organ/System-Specific RfCs:

System Basis RfC (mg/m3) POD UF Confidence
Developmental Decreased fetal weight 4 NOAEL: 367.75 mg/m3 100 Low/Medium
Other Decreased maternal weight 4 x 10-1 NOAEL: 124.25 mg/m3 300 Low/Medium

1,3,5-Trimethylbenzene is being reassessed.

Assessment Manager(s): Allen Davis (davis.allen@epa.gov)

Step Assessment Materials Released to the Public Release Date Public Meeting Date
1 Problem Formulation Materials N/A N/A
1 Preliminary Assessment Materials N/A N/A
4 Public Comment Draft 06/2012 N/A
4 Peer Review Draft 08/2013 06/2014
7 Post Final Assessment 09/2016

Please note: Any future dates displayed under Release Date are estimates and subject to change.

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