2,3,7,8-Tetrachlorodibenzo-p-dioxin

CASRN 1746-01-6

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (16 pp, 150 K) last updated: 02/17/2012

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
7 x10-10 Reproductive Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates LOAEL (ADJ): 2 x10-8
mg/kg-day
30
MF:
High
7 x10-10 Reproductive Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates LOAEL (ADJ): 2 x10-8
mg/kg-day
30 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (16 pp, 150 K)
Not assessed under the IRIS Program.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (16 pp, 150 K) last updated: 02/17/2012
Assessment underway at the time of the last significant revision.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 150 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 150 K)

Not assessed under the IRIS Program.


Feb 2012: Epa'S Reanalysis Of Key Issues Related To Dioxin Toxicity And Response To Nas Comments (Volume 1) (Interagency Science Discussion Draft) (Report)

May 2010: Epa'S Reanalysis Of Key Issues Related To Dioxin Toxicity And Response To Nas Comments (External Review Draft) (Report)

May 2010: Epa'S Response To &Quot;Health Risks From Dioxin And Related Compounds Evaluation Of The Epa Reassessment&Quot; Published By The National Research Council Of The National Academies (Interagency Science Consultation Draft) (Report)

Dec 2009: Epa'S Response To &Quot;Health Risks From Dioxin And Related Compounds: Evaluation Of The Epa Reassessment&Quot; Published By The National Research Council Of The National Academies (Other)

May 2009: Epa’S Science Plan For Activities Related To Dioxins In The Environment (Other)

Mar 2009: Percutaneous Absorption Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) From Soil (Journal Article) (Journal)

Feb 2009: 2009 Dioxin Re-Assessment Workshop (Other)

Sep 2008: An Exploratory Study: Assessment Of Modeled Dioxin Exposure In Ceramic Art Studios (2008 Final) (Report)

Nov 2006: An Inventory Of Sources And Environmental Releases Of Dioxin-Like Compounds In The U.S. For The Years 1987, 1995, And 2000 (Final, Nov 2006) (Report)

Oct 2004: Ambient Air Sampling For Dioxins, Furans And Coplanar Pcbs In An Urban Industrialized Corridor In Calcasieu Parish, Louisiana (Other)

Jan 2004: A Study To Evaluate The Levels Of Dioxin-Like Compounds In Dairy Feeds In The U.S. (Journal)

Jan 2004: An Assessment Of Dioxin Levels In Processed Ball Clay From The U.S. (Journal)

Apr 2003: Analyses Of Laboratory And Field Studies Of Reproductive Toxicity In Birds Exposed To Dioxin-Like Compounds For Use In Ecological Risk Assessment (Report)

Jan 2003: Exposure And Human Health Reassessment Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) And Related Compounds: Science Advisory Board (External Review Draft) (2000) (Report)

May 2002: Health Assessment Document For Polychlorinated Dibenzo-P-Dioxins (1985) (Report)

Apr 2002: A Pharmacokinetic Model For Estimating Exposure Of Americans To Dioxin-Like Compounds In The Past, Present, And Future (Journal)

Jan 2000: A Study Of The Mass Balance Of Dioxins And Furans In Lactating Cows In Background Conditions (Journal)

Jan 1999: A Study Of The Diurnal And Nocturnal Measurement Of Polychlorinated Dibenzo-P-Dioxins (Cdds) And Polychlorinated Dibenzofurans (Cdfs) In Ambient Air (Other)

Jan 1998: A National Survey Of Dioxin-Like Compounds In The U.S. Milk Supply (Journal)

Jan 1997: A Statistical Survey Of Dioxin-Like Compounds In U.S. Pork Fat (Journal)

Jan 1997: A Statistical Survey Of Dioxin-Like Compounds In U.S. Poultry Fat (Journal)

Feb 1996: A Statistical Survey Of Dioxin-Like Compounds In U.S. Beef: A Progress Report (Journal)

Sep 1994: Dioxin Exposure Initiative (Dei) (Other)

Mar 1989: Interim Procedures For Estimating Risks Associated With Exposures To Mixtures Of Chlorinated Dibenzo-P-Dioxins And -Dibenzofurans (Cdds And Cdfs) And 1989 Update (Report)

Sep 1986: Health Risk Assessment Approach For 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (1985) (Report)

Sep 1984: Health Effects Assessment For 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (1984) (Report)

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