Methyl chloride

CASRN 74-87-3, --

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) last updated: 07/17/2001
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 165 K) last updated: 07/17/2001

RfC (mg/m3) System Basis PoD Composite UF Confidence
9 x10-2 Nervous Cerebellar lesions NOAEL (HEC): 9.46 x101
mg/m3
1000 Medium

Cancer Assessment


Weight of Evidence for Cancer (PDF) (23 pp, 165 K) last updated: 07/17/2001

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Carcinogenic potential cannot be determined Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Applying the criteria for evaluating the overall weight-of-evidence for carcinogenicity to humans outlined in EPA's guidelines for carcinogen risk assessment (U.S. EPA, 1986), methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. Using the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the available data suggest that methyl chloride would be classified as an agent whose carcinogenic potential cannot be determined.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

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