Bromate

CASRN 15541-45-4

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 186 K) last updated: 06/06/2001

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
4 x10-3 Urinary Renal effects: urothelial hyperplasia NOAEL : 1.1
mg/kg-day
300 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 186 K) last updated: 06/06/2001
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (27 pp, 186 K) last updated: 06/06/2001

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Carcinogenic potential cannot be determined (Inhalation route) Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Known/likely human carcinogen (Oral route) Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Under the current Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986), bromate would be classified as B2, probable human carcinogen. Under the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), bromate should be evaluated as a likely human carcinogen by the oral route of exposure. Insufficient data are available to evaluate the human carcinogenic potential of bromate by the inhalation route.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 186 K)

Oral Slope Factor: 7 x10 -1 per mg/kg-day
Drinking Water Unit Risk: 2 x10 -5 per µg/L
Extrapolation Method: Time-to-tumor, Weibull
Tumor site(s): Reproductive, Urinary, Endocrine
Tumor type(s): Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma (DeAngelo et al., 1998)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 186 K)

Information reviewed but value not estimated.

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