IRIS

Methyl methacrylate

CASRN 80-62-6

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (31 pp, 204 K) last updated: 03/02/1998

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
None 1.4 None NOAEL : 1.36 x 102
mg/kg-day
100 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (31 pp, 204 K) last updated: 03/02/1998

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous, Respiratory 7 x 10-1 Degeneration/ atrophy of olfactory epithelium (male rats) BMC10 (HEC): 7.2
mg/m3
10 Medium/High
Nervous, Respiratory 7 x 10-1 Degeneration/ atrophy of olfactory epithelium (male rats) BMC10 (HEC): 7.2
mg/m3
10 Medium/High

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (31 pp, 204 K) last updated: 03/02/1998

WOE Characterization Framework for WOE Characterization
E (Evidence of non-carcinogenicity for humans) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Not likely to be carcinogenic to humans Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996)
Basis:
  • Under EPA's 1986 Guidelines for Carcinogen Risk Assessment, MMA would be classified as evidence of non-carcinogenicity for humans or a Group E chemical. Under the Proposed Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 1996), MMA is considered not likely to be carcinogenic to humans by any route of exposure because it has been evaluated in four well-conducted chronic inhalation studies in three appropriate animal species without demonstrating carcinogenic effects.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (31 pp, 204 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (31 pp, 204 K)

Not assessed under the IRIS Program.

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