IRIS

Phosgene

CASRN 75-44-5

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 166 K) last updated: 01/31/2006
Information reviewed but value not estimated.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 166 K) last updated: 01/31/2006

System RfC (mg/m3) Basis PoD Composite UF Confidence
Respiratory 3 x 10-4 Collagen staining indicative of fibrosis BMDL10 (HEC): 3 x 10-2
mg/m3
100 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (22 pp, 166 K) last updated: 01/31/2006

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), there is inadequate information to assess carcinogenic potential of phosgene. A single epidemiology study was not considered adequate for evaluating carcinogenic potential in humans, and no animal cancer bioassays of phosgene have been conducted.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 166 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 166 K)

Not assessed under the IRIS Program.

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