IRIS

Manganese

CASRN 7439-96-5

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (48 pp, 265 K) last updated: 11/01/1995

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 1.4 x 10-1 CNS effects NOAEL : 1.4 x 10-1
mg/kg-day
1 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (48 pp, 265 K) last updated: 12/01/1993

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 5 x 10-5 Impairment of neurobehavioral function LOAEL (HEC): 5 x 10-2
mg/m3
1000 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (48 pp, 265 K) last updated: 09/26/1988

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (US EPA, 1986)
Basis:
  • Existing studies are inadequate to assess the carcinogenicity of manganese.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (48 pp, 265 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (48 pp, 265 K)

Not assessed under the IRIS Program.

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