IRIS

Acephate

CASRN 30560-19-1 | DTXSID8023846

  • Archived IRIS Summary (PDF) (13 pp, 114 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

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This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 114 K) Archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 4 x 10-3 Inhibition of brain ChE LEL : 1.2 x 10-1
mg/kg-day
30 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 114 K) Archived on: 07/15/2016
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 114 K) Archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 114 K)

Oral Slope Factor: 8.7 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 2.5 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver adenomas and carcinomas (Chevron Chemical, 1982a)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 114 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

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