IRIS

Butyl benzyl phthalate (BBP)

CASRN 85-68-7 | DTXSID3020205

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 111 K) Last Updated: 09/01/1989

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic 2 x 10-1 Significantly increased liver-to-body weight and liver-to-brain weight ratios NOAEL : 1.59 x 102
mg/kg-day
1000 Low

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 111 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 111 K) Last Updated: 08/22/1988

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on statistically significant increase in mononuclear cell leukemia in female rats; the response in male rats was inconclusive and there was no such response in mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 111 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 111 K)

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Note: The butyl benzyl phthalate (bbp) (re)assessment has been discontinued. A new/updated assessment will not be added to the IRIS database at this time.

Assessment Manager(s): Dahnish Shams (shams.dahnish@epa.gov)

Step Assessment Materials Released to the Public Release Date Public Meeting Date
1 Preliminary Assessment Materials 09/2014 02/2015
  Discontinued 12/2018  

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