IRIS

Folpet

CASRN 133-07-3

  • Archived IRIS Summary (PDF) (13 pp, 115 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

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This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Other 1 x 10-1 Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels) NOEL : 1.0 x 101
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) archived on: 07/15/2016
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 3.5 x 10 -3 per mg/kg-day
Drinking Water Unit Risk: 1.0 x 10 -7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Digestive tract tumors (adenoma and/ or adenocarcinoma) (Chevron, 1982)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Not Assessed under the IRIS Program.

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