CASRN 7440-43-9 | DTXSID1023940
- IRIS Summary (PDF) (13 pp, 118 K)
Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 118 K)
Last Updated: 10/01/1989
|System||RfD (mg/kg-day)||Basis||PoD||Composite UF||Confidence|
5 x 10-4
: 5 x 10-3
1 x 10-3
: 1 x 10-2
Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 118 K)
Not assessed under the IRIS Program.
Weight of Evidence for Cancer (PDF) (13 pp, 118 K)
Last Updated: 03/31/1987
|WOE Characterization||Framework for WOE Characterization|
|B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans)||Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)|
- Limited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response.
- This may be a synopsis of the full weight-of-evidence narrative.
Not Assessed under the IRIS Program.
Inhalation Unit Risk:
1.8 x 10 -3 per µg/m3
Extrapolation Method: Two stage; only first affected by exposure; extra risk
Tumor site(s): Respiratory
Tumor type(s): Lung, trachea, bronchus cancer deaths (Thun et al., 1985)
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
You will need Adobe Reader to view some of the files on this page. See EPA’s PDF page to learn more.