2,4,6-Trichlorophenol
CASRN 88-06-2 | DTXSID5021386
- IRIS Summary (PDF) (13 pp, 115 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K)
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K)
Last Updated: 07/01/1991
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF) (13 pp, 115 K)
Last Updated: 06/01/1990
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemias in male rats and hepatocellular adenomas or carcinomas in male and female mice.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)
Oral Slope Factor:
1.1 x 10 -2 per mg/kg-day
Drinking Water Unit Risk:
3.1 x 10 -7 per µg/L
Extrapolation Method:
Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)
Inhalation Unit Risk:
3.1 x 10 -6 per µg/m3
Extrapolation Method:
Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)
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Tumor Sites
Chemical Structure for
2,4,6-Trichlorophenol
