Toluene
CASRN 108-88-3 | DTXSID7021360
- Toxicological Review (PDF) (179 pp, 1.80 M)
- IRIS Summary (PDF) (35 pp, 230 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (35 pp, 230 K)
Last Updated: 09/23/2005
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Urinary | 8 x 10-2 | Increased kidney weight |
BMDL
: 238 mg/kg-day |
3000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (35 pp, 230 K)
Last Updated: 09/23/2005
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 5 | Neurological effects in occupationally-exposed workers |
NOAEL
(ADJ): 46 mg/m3 |
10 | High |
Cancer Assessment
Weight of Evidence for Cancer (PDF) (35 pp, 230 K)
Last Updated: 09/23/2005
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Inadequate information to assess carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess the carcinogenic potential of toluene because studies of humans chronically exposed to toluene are inconclusive, toluene was not carcinogenic in adequate inhalation cancer bioassays of rats and mice exposed for life (CIIT, 1980 NTP, 1990 Huff, 2003), and increased incidences of mammary cancer and leukemia were reported in a lifetime rat oral bioassay at a dose level of 500 mg/kg-day but not at 800 mg/kg-day (Maltoni et al., 1997).
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (35 pp, 230 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (35 pp, 230 K)
Not assessed under the IRIS Program.
Additional EPA toxicity information may be available by visiting the following sites:
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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