IRIS

Tetrachloroethylene

CASRN 127-18-4

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (38 pp, 350 K) last updated: 02/10/2012

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous, Ocular 6 x 10-3 (See Note) Medium


Note: The RfD was derived as a midpoint of two candidate RfDs from studies that reported neurotoxicity in occupationally-exposed adults: 0.0097 mg/kg-day based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.0026 mg/kg-day based on changes in color vision (Cavalleri et al., 1994). See Section I.A.1 of the IRIS Summary for Tetrachloroethylene for more information. Fix this one.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (38 pp, 350 K) last updated: 02/10/2012

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous, Ocular 4 x 10-2 Neurotoxicity (color vision) LOAEL : 15
mg/m3
1000 Medium
Nervous, Ocular x 10


Note: The RfC was derived as a midpoint of two candidate RfCs from studies that reported neurotoxicity in occupationally-exposed adults: 0.056 mg/m3 based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.015 mg/m3 based on changes in color vision (Cavalleri et al., 1994). See Section I.B.1 of the IRIS Summary for Tetrachloroethylene for more information.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (38 pp, 350 K) last updated: 02/10/2012

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Following EPA (2005a) Guidelines for Carcinogen Risk Assessment, tetrachloroethylene is "likely to be carcinogenic in humans by all routes of exposure."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (38 pp, 350 K)

Oral Slope Factor: 2.1 x10 -3 per mg/kg-day
Drinking Water Unit Risk: 6.1 x10 -8 per µg/L
Extrapolation Method: Multistage model (with linear extrapolation from the point of departure (BMDL10), followed by route-to-route extrapolation to the oral route and interspecies extrapolation using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)



Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (38 pp, 350 K)

Inhalation Unit Risk: 2.6 x10 -7 per µg/m3
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMCL10), followed by extrapolation to humans using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)


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