IRIS

Oryzalin

CASRN 19044-88-3

  • Archived IRIS Summary (PDF) (12 pp, 108 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

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This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 108 K) archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine, Hepatic, Urinary 5 x 10-2 Increases in serum cholesterol, alkaline phosphatase, and relative liver and kidney weights, and decreases in alanine transaminase and adrenal weights NOEL : 5
mg/kg-day
100 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 108 K) archived on: 07/15/2016
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 108 K) archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Oryzalin produced tumors (generally benign) at multiple sites in male and female rats. It is structurally related to 2,4-diaminoanisole sulfate which causes malignant tumors at similar sites.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 108 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 108 K)

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

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