Heptachlor
CASRN 76-44-8 | DTXSID3020679
- IRIS Summary (PDF) (14 pp, 122 K)
- Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(14 pp, 122 K)
Last Updated: 09/30/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 5 x 10 -4 | Liver weight increases in males |
NOEL
:
1.5
x 10-1 mg/kg-day |
300 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(14 pp, 122 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 122 K)
Last Updated: 09/30/1987
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Inadequate human data, but sufficient evidence exist from studies in which benign and malignant liver tumors were induced in three strains of mice of both sexes. Several structurally related compounds are liver carcinogens.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 122 K)
Oral Slope Factor:
4.5
per mg/kg-day
Drinking Water Unit Risk:
1.3
x 10-4
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas (Davis, 1965; NCI, 1977)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 122 K)
Inhalation Unit Risk:
1.3
x 10-3
per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas (Davis, 1965; NCI, 1977)
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.
Contact Us to ask a question, provide feedback or report a problem.
