Trichloropropane CASRN 96-18-4 | IRIS

IRIS

1,2,3-Trichloropropane

CASRN 96-18-4 | DTXSID9021390

Toxicological Review (PDF) (247 pp, 1.91 M)
IRIS Summary (PDF) (33 pp, 283 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 283 K) Last Updated: 09/30/2009

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	4 x 10 ^-3	Increased absolute liver weight in male rats	BMDL (ADJ): 1.1 mg/kg-day	300	Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 283 K) Last Updated: 09/30/2009

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	3 x 10 ^-4	peribronchial lymphoid hyperplasia in male rats	BMCL (HEC): 0.90 mg/m³	3000	Low

Cancer Assessment

Weight of Evidence for Cancer (PDF) (33 pp, 283 K) Last Updated: 09/30/2009

WOE Characterization	Framework for WOE Characterization
Likely to be carcinogenic to humans	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 2005), 1,2,3-trichloropropane is "likely to be carcinogenic to humans", based on a statistically significant and dose-related increase in the formation of multiple tumors in both sexes of two species from an NTP (1993) chronic oral bioassay.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 283 K)

Oral Slope Factor: 3 x 10¹ per mg/kg-day
Extrapolation Method: Multistage-Weibull model with linear extrapolation from the point of departure (BMDL₁₀).
Tumor site(s): Hepatic, Gastrointestinal, Ocular, Reproductive
Tumor type(s): alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas (NTP, 1993)
Note: ADAF -- EPA has concluded that 1,2,3-trichloropropane is carcinogenic by a mutagenic mode of action. Application of age-dependent adjustment factors (ADAFs) to the oral slope factor is recommended in combination with appropriate exposure data when assessing risk associated with early-life exposure.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 283 K)

Not Assessed under the IRIS Program.

Oct 2009: IRIS Toxicological Review of 1,2,3-trichloropropane (Interagency Science Discussion Draft) (Report)

Sep 2009: IRIS Toxicological Review and Summary Documents For 1,2,3-Trichloropropane (Report)

Nov 2007: IRIS Toxicological Review of 1,2,3-Trichloropropane (External Review Draft) (Report)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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