IRIS

Tetrahydrofuran

CASRN 109-99-9

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (26 pp, 242 K) last updated: 02/21/2012

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Developmental 9 x 10-1 Decreased pup body weight gain BMDL1SD : 928
mg/kg-day
1000 Low/Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (26 pp, 242 K) last updated: 02/21/2012

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous, Hepatic 2 Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis) BMCL10 : 246 x 10-12
mg/m3
100 Medium/High
Nervous, Hepatic 2 Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis) BMCL10 : 246 x 10-12
mg/m3
100 Medium/High

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (26 pp, 242 K) last updated: 02/21/2012

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for THF provides "suggestive evidence of carcinogenic potential."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 242 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (26 pp, 242 K)

Not assessed under the IRIS Program.

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