IRIS

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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

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cancer
Chemical Name CASRN Exposure Route WOE Characterization Tumor Type Toxicity Value
Acetaldehyde 75-07-0 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal squamous cell carcinoma or adenocarcinoma 2.2x10-6
per µg/m3
Acrylamide 79-06-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
thyroid tumors and tunica vaginalis mesotheliomas 1x10-4
per µg/m3
Acrylamide 79-06-1 Oral Likely to be carcinogenic to humans (2005 guidelines)
thyroid tumors and tunica vaginalis mesotheliomas 5x10-1
per mg/kg-day
Acrylonitrile 107-13-1 Oral B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Brain and spinal cord astrocytomas, Zymbal gland carcinomas and stomach papillomas/ carcinomas 5.4x10-1
per mg/kg-day
Acrylonitrile 107-13-1 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Respiratory cancer 6.8x10-5
per µg/m3
Aldrin 309-00-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.9x10-3
per µg/m3
Aldrin 309-00-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 1.7x101
per mg/kg-day
Aniline 62-53-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Spleen, combined fibrosarcoma, stromal sarcoma, capsular sarcoma and hemangiosarcoma 5.7x10-3
per mg/kg-day
Aramite 140-57-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic liver nodules and carcinomas 7.1x10-6
per µg/m3
Aramite 140-57-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic liver nodules and carcinomas 2.5x10-2
per mg/kg-day
Arsenic, Inorganic 7440-38-2 Oral A (Human carcinogen) (1986 guidelines)
Skin cancer 1.5
per mg/kg-day
Arsenic, Inorganic 7440-38-2 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 4.3x10-3
per µg/m3
Asbestos 1332-21-4 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer and mesothelioma 2.3x10-1
per f/mL
Azobenzene 103-33-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Abdominal cavity sarcomas 1.1x10-1
per mg/kg-day
Azobenzene 103-33-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Abdominal cavity sarcomas 3.1x10-5
per µg/m3
Benzene 71-43-2 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Leukemia 1.5x10-2
per mg/kg-day
Benzene 71-43-2 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Leukemia 7.8x10-6
per µg/m3
Benzene 71-43-2 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Leukemia 2.2x10-6
per µg/m3
Benzene 71-43-2 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Leukemia 5.5x10-2
per mg/kg-day
Benzidine 92-87-5 Inhalation A (Human carcinogen) (1986 guidelines)
Bladder tumors 6.7x10-2
per µg/m3
Benzidine 92-87-5 Oral A (Human carcinogen) (1986 guidelines)
Bladder tumors 2.3x102
per mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Inhalation Carcinogenic to humans (2005 guidelines)
Squamous cell neoplasia in the larynx, pharynx, trachea, nasal cavity, esophagus, and forestomach. 6x10-4
per µg/m3
Benzo[a]pyrene (BaP) 50-32-8 Oral Carcinogenic to humans (2005 guidelines)
forestomach, esophagus, tongue, and larynx tumors 1
per mg/kg-day
Benzotrichloride 98-07-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Lung, adenocarcinoma 1.3x101
per mg/kg-day
Benzyl chloride 100-44-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Thyroid, C-cell adenoma/ carcinoma 1.7x10-1
per mg/kg-day
Beryllium and compounds 7440-41-7 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
Known/likely human carcinogen (1996 guidelines)
Lung cancer 2.4x10-3
per µg/m3
Biphenyl 92-52-4 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver adenomas or carcinomas 8x10-3
per mg/kg-day
Bis(chloroethyl)ether (BCEE) 111-44-4 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatomas 3.3x10-4
per µg/m3
Bis(chloroethyl)ether (BCEE) 111-44-4 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatomas 1.1
per mg/kg-day
Bis(chloromethyl)ether (BCME) 542-88-1 Inhalation A (Human carcinogen) (1986 guidelines)
Respiratory tract tumors 6.2x10-2
per µg/m3
Bis(chloromethyl)ether (BCME) 542-88-1 Oral A (Human carcinogen) (1986 guidelines)
Respiratory tract tumors 2.2x102
per mg/kg-day
Bromate 15541-45-4 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
Known/likely human carcinogen (1996 guidelines)
Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma 7x10-1
per mg/kg-day
Bromodichloromethane 75-27-4 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Kidney (tubular cell adenoma and tubular cell adenocarcinoma) 6.2x10-2
per mg/kg-day
Bromoform 75-25-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic lesions in the large intestine 1.1x10-6
per µg/m3
Bromoform 75-25-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic lesions in the large intestine 7.9x10-3
per mg/kg-day
1,3-Butadiene 106-99-0 Inhalation Carcinogenic to humans (1999 guidelines)
Leukemia 3x10-5
per µg/m3
Cadmium 7440-43-9 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Lung, trachea, bronchus cancer deaths 1.8x10-3
per µg/m3
Carbon tetrachloride 56-23-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenoma or carcinoma 7x10-2
per mg/kg-day
Carbon tetrachloride 56-23-5 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Pheochromocytoma 6x10-6
per µg/m3
Chlordane (Technical) 12789-03-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular carcinoma 1x10-4
per µg/m3
Chlordane (Technical) 12789-03-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular carcinoma 3.5x10-1
per mg/kg-day
Chlordecone (Kepone) 143-50-0 Oral Likely to be carcinogenic to humans (2005 guidelines)
liver hepatocellular carcinoma 1x101
per mg/kg-day
Chloroform 67-66-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Likely to be carcinogenic to humans (1999 guidelines)
Not likely to be carcinogenic to humans (1999 guidelines)
Hepatocellular carcinoma 2.3x10-5
per µg/m3
Chloroprene 126-99-8 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma 3x10-4
per µg/m3
Chromium(VI) 18540-29-9 Inhalation A (Human carcinogen) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
D (Not classifiable as to human carcinogenicity) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Lung cancer 1.2x10-2
per µg/m3
Coke oven emissions Inhalation A (Human carcinogen) (1986 guidelines)
Respiratory cancer 6.2x10-4
per µg/m3
2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) 1163-19-5 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver neoplastic nodules or carcinoma (combined) 7x10-4
per mg/kg-day
Di (2-ethylhexyl)phthalate (DEHP) 117-81-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 1.4x10-2
per mg/kg-day
Di(2-ethylhexyl)adipate 103-23-1 Oral C (Possible human carcinogen) (1986 guidelines)
Combined hepatocellular adenomas and carcinomas 1.2x10-3
per mg/kg-day
Dibromochloromethane 124-48-1 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 8.4x10-2
per mg/kg-day
1,2-Dibromoethane 106-93-4 Oral Likely to be carcinogenic to humans (1999 guidelines)
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas 1
mg/kg-day

(central tendency estimate)
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 6x10-4
per µg/m3

(95% upper bound)
1,2-Dibromoethane 106-93-4 Oral Likely to be carcinogenic to humans (1999 guidelines)
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas 2
per mg/kg-day

(95% upper bound)
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 3x10-4
per µg/m3

(central tendency estimate)
Dichloroacetic acid 79-43-6 Oral Likely to be carcinogenic to humans (1999 guidelines)
Hepatoadenoma and Hepatocarcinoma 5x10-2
per mg/kg-day
3,3'-Dichlorobenzidine 91-94-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Mammary adenocarcinoma 4.5x10-1
per mg/kg-day
p,p'-Dichlorodiphenyl dichloroethane (DDD) 72-54-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 2.4x10-1
per mg/kg-day
p,p'-Dichlorodiphenyldichloroethylene (DDE) 72-55-9 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas, hepatomas 3.4x10-1
per mg/kg-day
p,p'-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors, benign and malignant 9.7x10-5
per µg/m3
p,p'-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors, benign and malignant 3.4x10-1
per mg/kg-day
1,2-Dichloroethane 107-06-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hemangiosarcomas 9.1x10-2
per mg/kg-day
1,2-Dichloroethane 107-06-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hemangiosarcomas 2.6x10-5
per µg/m3
Dichloromethane 75-09-2 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas 1x10-8
per µg/m3
Dichloromethane 75-09-2 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular carcinomas or adenomas 2x10-3
per mg/kg-day
1,3-Dichloropropene 542-75-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular adenoma/carcinoma 5x10-2
per mg/kg-day
1,3-Dichloropropene 542-75-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Bronchioalveolar adenoma 4x10-6
per µg/m3
1,3-Dichloropropene 542-75-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular adenoma/carcinoma 5x10-2
per mg/kg-day
1,3-Dichloropropene 542-75-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Urinary bladder carcinoma 1x10-1
per mg/kg-day
Dichlorvos 62-73-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Forestomach tumors, pancreatic acinar adenoma, leukemia 2.9x10-1
per mg/kg-day
Dieldrin 60-57-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 1.6x101
per mg/kg-day
Dieldrin 60-57-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.6x10-3
per µg/m3
2,4-/2,6-Dinitrotoluene mixture Various Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas 6.8x10-1
per mg/kg-day
1,4-Dioxane 123-91-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) 5x10-6
per µg/m3
1,4-Dioxane 123-91-1 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenoma and carcinoma 1x10-1
per mg/kg-day
1,2-Diphenylhydrazine 122-66-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic liver nodules 8.0x10-1
per mg/kg-day
1,2-Diphenylhydrazine 122-66-7 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic liver nodules 2.2x10-4
per µg/m3
Epichlorohydrin 106-89-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity tumors 1.2x10-6
per µg/m3
Epichlorohydrin 106-89-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Papillomas and carcinomas of the forestomach 9.9x10-3
per mg/kg-day
Ethylene oxide 75-21-8 Inhalation Carcinogenic to humans (2005 guidelines)
Lymphoid cancer, (female) breast cancer 3x10-3
per µg/m3
Formaldehyde 50-00-0 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Squamous cell carcinoma 1.3x10-5
per µg/m3
Furmecyclox 60568-05-0 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Combined liver nodules and carcinomas 3.0x10-2
per mg/kg-day
Heptachlor 76-44-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 1.3x10-3
per µg/m3
Heptachlor 76-44-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 4.5
per mg/kg-day
Heptachlor epoxide 1024-57-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 2.6x10-3
per µg/m3
Heptachlor epoxide 1024-57-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 9.1
per mg/kg-day
Hexachlorobenzene 118-74-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma 4.6x10-4
per µg/m3
Hexachlorobenzene 118-74-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma 1.6
per mg/kg-day
Hexachlorobutadiene 87-68-3 Inhalation C (Possible human carcinogen) (1986 guidelines)
Renal tubular adenomas and adenocarcinomas 2.2x10-5
per µg/m3
Hexachlorobutadiene 87-68-3 Oral C (Possible human carcinogen) (1986 guidelines)
Renal tubular adenomas and adenocarcinomas 7.8x10-2
per mg/kg-day
alpha-Hexachlorocyclohexane (alpha-HCH) 319-84-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 1.8x10-3
per µg/m3
alpha-Hexachlorocyclohexane (alpha-HCH) 319-84-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 6.3
per mg/kg-day
beta-Hexachlorocyclohexane (beta-HCH) 319-85-7 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 1.8
per mg/kg-day
beta-Hexachlorocyclohexane (beta-HCH) 319-85-7 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 5.3x10-4
per µg/m3
technical Hexachlorocyclohexane (t-HCH) 608-73-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver nodules and hepatocellular carcinomas 1.8
per mg/kg-day
technical Hexachlorocyclohexane (t-HCH) 608-73-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver nodules and hepatocellular carcinomas 5.1x10-4
per µg/m3
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) 6.2x103
per mg/kg-day
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) 1.3
per µg/m3
Hexachloroethane 67-72-1 Oral Likely to be carcinogenic to humans (2005 guidelines)
Renal adenomas and carcinomas (combined) 4x10-2
per mg/kg-day
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) 121-82-4 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) 8x10-2
per mg/kg-day
Hydrazine/Hydrazine sulfate 302-01-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity adenoma or adenocarcinoma 4.9x10-3
per µg/m3
Hydrazine/Hydrazine sulfate 302-01-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatoma 3.0
per mg/kg-day
Isophorone 78-59-1 Oral C (Possible human carcinogen) (1986 guidelines)
Preputial gland carcinoma 9.5x10-4
per mg/kg-day
Libby Amphibole Asbestos 1318-09-8 Inhalation Carcinogenic to humans (2005 guidelines)
Cancer mortality from lung cancer and mesothelioma 1.7x10-1
per fiber/cc
4,4'-Methylene bis(N,N'-dimethyl)aniline 101-61-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Thyroid, follicular cell carcinoma/ adenoma 4.6x10-2
per mg/kg-day
Nickel refinery dust Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 2.4x10-4
per µg/m3
Nickel subsulfide 12035-72-2 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 4.8x10-4
per µg/m3
Nitrobenzene 98-95-3 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas 4x10-5
per µg/m3
N-Nitroso-N-methylethylamine 10595-95-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 2.2x101
per mg/kg-day
N-Nitroso-di-n-butylamine 924-16-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Bladder and esophagus tumors 1.6x10-3
per µg/m3
N-Nitroso-di-n-butylamine 924-16-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Bladder and esophagus tumors 5.4
per mg/kg-day
N-Nitrosodi-N-propylamine 621-64-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 7.0
per mg/kg-day
N-Nitrosodiethanolamine 1116-54-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma, cholangiocellular carcinoma and adenoma and neoplastic nodules 2.8
per mg/kg-day
N-Nitrosodiethylamine 55-18-5 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 1.5x102
per mg/kg-day
N-Nitrosodiethylamine 55-18-5 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 4.3x10-2
per µg/m3
N-Nitrosodimethylamine 62-75-9 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 1.4x10-2
per µg/m3
N-Nitrosodimethylamine 62-75-9 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 5.1x101
per mg/kg-day
N-Nitrosodiphenylamine 86-30-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Transitional cell carcinoma of the bladder 4.9x10-3
per mg/kg-day
N-Nitrosopyrrolidine 930-55-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 6.1x10-4
per µg/m3
N-Nitrosopyrrolidine 930-55-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 2.1
per mg/kg-day
Pentachlorophenol 87-86-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas 4x10-1
per mg/kg-day
Polychlorinated Biphenyls (PCBs) 1336-36-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas 1x10-4
per µg/m3

(Applies to inhalation of evaporated congeners)
Polychlorinated Biphenyls (PCBs) 1336-36-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas 2
per mg/kg-day
Prochloraz 67747-09-5 Oral C (Possible human carcinogen) (1986 guidelines)
Liver adenoma/ carcinoma combined 1.5x10-1
per mg/kg-day
Propylene oxide 75-56-9 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Forestomach, squamous cell carcinoma 2.4x10-1
per mg/kg-day
Propylene oxide 75-56-9 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity hemangioma or hemangiosarcoma 3.7x10-6
per µg/m3
Quinoline 91-22-5 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatic hemangioendotheliomas or hemangiosarcomas 3
per mg/kg-day
1,1,1,2-Tetrachloroethane 630-20-6 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 7.4x10-6
per µg/m3
1,1,1,2-Tetrachloroethane 630-20-6 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 2.6x10-2
per mg/kg-day
1,1,2,2-Tetrachloroethane 79-34-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
hepatocellular carcinomas 2x10-1
per mg/kg-day
Tetrachloroethylene 127-18-4 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas 0

Tetrachloroethylene 127-18-4 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas 2.1x10-3
per mg/kg-day
Toxaphene 8001-35-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic nodules 3.2x10-4
per µg/m3
Toxaphene 8001-35-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic nodules 1.1
per mg/kg-day
Trichloroacetic acid 76-03-9 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Hepatocellular adenomas or carcinomas 7x10-2
per mg/kg-day
1,1,2-Trichloroethane 79-00-5 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatocellular carcinoma 1.6x10-5
per µg/m3
1,1,2-Trichloroethane 79-00-5 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular carcinoma 5.7x10-2
per mg/kg-day
Trichloroethylene 79-01-6 Oral Carcinogenic to humans (2005 guidelines)
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors 4.6 x10-2
per mg/kg-day
Trichloroethylene 79-01-6 Inhalation Carcinogenic to humans (2005 guidelines)
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors 4.1x10-6
per µg/m3
2,4,6-Trichlorophenol 88-06-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Leukemia 3.1x10-6
per µg/m3
2,4,6-Trichlorophenol 88-06-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Leukemia 1.1x10-2
per mg/kg-day
1,2,3-Trichloropropane 96-18-4 Oral Likely to be carcinogenic to humans (2005 guidelines)
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas 3x101
per mg/kg-day
Trifluralin 1582-09-8 Oral C (Possible human carcinogen) (1986 guidelines)
Combined renal pelvis carcinomas, urinary bladder papillomas and/or thyroid adenomas and carcinomas 7.7x10-3
per mg/kg-day
2,4,6-Trinitrotoluene (TNT) 118-96-7 Oral C (Possible human carcinogen) (1986 guidelines)
Urinary bladder, transitional cell papilloma and transitional squamous cell carcinomas 3.0x10-2
per mg/kg-day
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 4.4x10-6
per µg/m3

(Continuous lifetime exposure during adulthood)
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 8.8x10-6
per µg/m3

(Continuous lifetime exposure from birth)
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 4.4x10-6
per µg/m3

(Continuous lifetime exposure during adulthood)
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 1.5
per mg/kg-day

(Continuous lifetime exposure from birth)
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 7.2x10-1
per mg/kg-day

(Continuous lifetime exposure during adulthood)
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 7.5x10-1
per mg/kg-day

(Continuous lifetime exposure during adulthood)
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 1.4
per mg/kg-day

(Continuous lifetime exposure from birth)
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 8.8x10-6
per µg/m3

(Continuous lifetime exposure from birth)