IRIS Advanced Search
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.
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cancer| Chemical Name | CASRN | Exposure Route | WOE Characterization | Tumor Type | Toxicity Value |
|---|---|---|---|---|---|
| Acetaldehyde | 75-07-0 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal squamous cell carcinoma or adenocarcinoma |
2.2x10-6 per µg/m3 |
| Acrylamide | 79-06-1 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
thyroid tumors and tunica vaginalis mesotheliomas |
5x10-1 per mg/kg-day |
| Acrylamide | 79-06-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
thyroid tumors and tunica vaginalis mesotheliomas |
1x10-4 per µg/m3 |
| Acrylonitrile | 107-13-1 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Respiratory cancer |
6.8x10-5 per µg/m3 |
| Acrylonitrile | 107-13-1 | Oral |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Brain and spinal cord astrocytomas, Zymbal gland carcinomas and stomach papillomas/ carcinomas |
5.4x10-1 per mg/kg-day |
| Aldrin | 309-00-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma |
4.9x10-3 per µg/m3 |
| Aldrin | 309-00-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma |
1.7x101 per mg/kg-day |
| Aniline | 62-53-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Spleen, combined fibrosarcoma, stromal sarcoma, capsular sarcoma and hemangiosarcoma |
5.7x10-3 per mg/kg-day |
| Aramite | 140-57-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic liver nodules and carcinomas |
7.1x10-6 per µg/m3 |
| Aramite | 140-57-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic liver nodules and carcinomas |
2.5x10-2 per mg/kg-day |
| Arsenic, Inorganic | 7440-38-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer |
4.3x10-3 per µg/m3 |
| Arsenic, Inorganic | 7440-38-2 | Oral |
A (Human carcinogen) (1986 guidelines) |
Skin cancer |
1.5 per mg/kg-day |
| Asbestos | 1332-21-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer and mesothelioma |
2.3x10-1 per f/mL |
| Azobenzene | 103-33-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Abdominal cavity sarcomas |
3.1x10-5 per µg/m3 |
| Azobenzene | 103-33-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Abdominal cavity sarcomas |
1.1x10-1 per mg/kg-day |
| Benzene | 71-43-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Leukemia |
2.2x10-6 per µg/m3 |
| Benzene | 71-43-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Leukemia |
7.8x10-6 per µg/m3 |
| Benzene | 71-43-2 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Leukemia |
5.5x10-2 per mg/kg-day |
| Benzene | 71-43-2 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Leukemia |
1.5x10-2 per mg/kg-day |
| Benzidine | 92-87-5 | Oral |
A (Human carcinogen) (1986 guidelines) |
Bladder tumors |
2.3x102 per mg/kg-day |
| Benzidine | 92-87-5 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Bladder tumors |
6.7x10-2 per µg/m3 |
| Benzo[a]pyrene (BaP) | 50-32-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Squamous cell neoplasia in the larynx, pharynx, trachea, nasal cavity, esophagus, and forestomach. |
6x10-4 per µg/m3 |
| Benzo[a]pyrene (BaP) | 50-32-8 | Oral |
Carcinogenic to humans (2005 guidelines) |
forestomach, esophagus, tongue, and larynx tumors |
1 per mg/kg-day |
| Benzotrichloride | 98-07-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Lung, adenocarcinoma |
1.3x101 per mg/kg-day |
| Benzyl chloride | 100-44-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Thyroid, C-cell adenoma/ carcinoma |
1.7x10-1 per mg/kg-day |
| Beryllium and compounds | 7440-41-7 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) Carcinogenic potential cannot be determined (1996 guidelines) Known/likely human carcinogen (1996 guidelines) |
Lung cancer |
2.4x10-3 per µg/m3 |
| Biphenyl | 92-52-4 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver adenomas or carcinomas |
8x10-3 per mg/kg-day |
| Bis(chloroethyl)ether (BCEE) | 111-44-4 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatomas |
3.3x10-4 per µg/m3 |
| Bis(chloroethyl)ether (BCEE) | 111-44-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatomas |
1.1 per mg/kg-day |
| Bis(chloromethyl)ether (BCME) | 542-88-1 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Respiratory tract tumors |
6.2x10-2 per µg/m3 |
| Bis(chloromethyl)ether (BCME) | 542-88-1 | Oral |
A (Human carcinogen) (1986 guidelines) |
Respiratory tract tumors |
2.2x102 per mg/kg-day |
| Bromate | 15541-45-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Carcinogenic potential cannot be determined (1996 guidelines) Known/likely human carcinogen (1996 guidelines) |
Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma |
7x10-1 per mg/kg-day |
| Bromodichloromethane | 75-27-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Kidney (tubular cell adenoma and tubular cell adenocarcinoma) |
6.2x10-2 per mg/kg-day |
| Bromoform | 75-25-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic lesions in the large intestine |
7.9x10-3 per mg/kg-day |
| Bromoform | 75-25-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic lesions in the large intestine |
1.1x10-6 per µg/m3 |
| 1,3-Butadiene | 106-99-0 | Inhalation |
Carcinogenic to humans (1999 guidelines) |
Leukemia |
3x10-5 per µg/m3 |
| Cadmium | 7440-43-9 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Lung, trachea, bronchus cancer deaths |
1.8x10-3 per µg/m3 |
| Carbon tetrachloride | 56-23-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenoma or carcinoma |
7x10-2 per mg/kg-day |
| Carbon tetrachloride | 56-23-5 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Pheochromocytoma |
6x10-6 per µg/m3 |
| Chlordane (Technical) | 12789-03-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular carcinoma |
3.5x10-1 per mg/kg-day |
| Chlordane (Technical) | 12789-03-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular carcinoma |
1x10-4 per µg/m3 |
| Chlordecone (Kepone) | 143-50-0 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
liver hepatocellular carcinoma |
1x101 per mg/kg-day |
| Chloroform | 67-66-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Likely to be carcinogenic to humans (1999 guidelines) Not likely to be carcinogenic to humans (1999 guidelines) |
Hepatocellular carcinoma |
2.3x10-5 per µg/m3 |
| Chloroprene | 126-99-8 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma |
3x10-4 per µg/m3 |
| Chromium(VI) | 18540-29-9 | Inhalation |
A (Human carcinogen) (1986 guidelines) Carcinogenic potential cannot be determined (1996 guidelines) D (Not classifiable as to human carcinogenicity) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Lung cancer |
1.2x10-2 per µg/m3 |
| Coke oven emissions | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Respiratory cancer |
6.2x10-4 per µg/m3 |
|
| 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) | 1163-19-5 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver neoplastic nodules or carcinoma (combined) |
7x10-4 per mg/kg-day |
| Di (2-ethylhexyl)phthalate (DEHP) | 117-81-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma |
1.4x10-2 per mg/kg-day |
| Di(2-ethylhexyl)adipate | 103-23-1 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Combined hepatocellular adenomas and carcinomas |
1.2x10-3 per mg/kg-day |
| Dibromochloromethane | 124-48-1 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma |
8.4x10-2 per mg/kg-day |
| 1,2-Dibromoethane | 106-93-4 | Inhalation |
Likely to be carcinogenic to humans (1999 guidelines) |
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas |
3x10-4 per µg/m3 (central tendency estimate) |
| 1,2-Dibromoethane | 106-93-4 | Inhalation |
Likely to be carcinogenic to humans (1999 guidelines) |
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas |
6x10-4 per µg/m3 (95% upper bound) |
| 1,2-Dibromoethane | 106-93-4 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas |
2 per mg/kg-day (95% upper bound) |
| 1,2-Dibromoethane | 106-93-4 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas |
1 mg/kg-day (central tendency estimate) |
| Dichloroacetic acid | 79-43-6 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Hepatoadenoma and Hepatocarcinoma |
5x10-2 per mg/kg-day |
| 3,3'-Dichlorobenzidine | 91-94-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Mammary adenocarcinoma |
4.5x10-1 per mg/kg-day |
| p,p'-Dichlorodiphenyl dichloroethane (DDD) | 72-54-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors |
2.4x10-1 per mg/kg-day |
| p,p'-Dichlorodiphenyldichloroethylene (DDE) | 72-55-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas, hepatomas |
3.4x10-1 per mg/kg-day |
| p,p'-Dichlorodiphenyltrichloroethane (DDT) | 50-29-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors, benign and malignant |
3.4x10-1 per mg/kg-day |
| p,p'-Dichlorodiphenyltrichloroethane (DDT) | 50-29-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors, benign and malignant |
9.7x10-5 per µg/m3 |
| 1,2-Dichloroethane | 107-06-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hemangiosarcomas |
2.6x10-5 per µg/m3 |
| 1,2-Dichloroethane | 107-06-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hemangiosarcomas |
9.1x10-2 per mg/kg-day |
| Dichloromethane | 75-09-2 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas |
1x10-8 per µg/m3 |
| Dichloromethane | 75-09-2 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular carcinomas or adenomas |
2x10-3 per mg/kg-day |
| 1,3-Dichloropropene | 542-75-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Bronchioalveolar adenoma |
4x10-6 per µg/m3 |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular adenoma/carcinoma |
5x10-2 per mg/kg-day |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Urinary bladder carcinoma |
1x10-1 per mg/kg-day |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular adenoma/carcinoma |
5x10-2 per mg/kg-day |
| Dichlorvos | 62-73-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Forestomach tumors, pancreatic acinar adenoma, leukemia |
2.9x10-1 per mg/kg-day |
| Dieldrin | 60-57-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma |
4.6x10-3 per µg/m3 |
| Dieldrin | 60-57-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma |
1.6x101 per mg/kg-day |
| 2,4-/2,6-Dinitrotoluene mixture | Various | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas |
6.8x10-1 per mg/kg-day |
| 1,4-Dioxane | 123-91-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) |
5x10-6 per µg/m3 |
| 1,4-Dioxane | 123-91-1 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenoma and carcinoma |
1x10-1 per mg/kg-day |
| 1,2-Diphenylhydrazine | 122-66-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic liver nodules |
8.0x10-1 per mg/kg-day |
| 1,2-Diphenylhydrazine | 122-66-7 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic liver nodules |
2.2x10-4 per µg/m3 |
| Epichlorohydrin | 106-89-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity tumors |
1.2x10-6 per µg/m3 |
| Epichlorohydrin | 106-89-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Papillomas and carcinomas of the forestomach |
9.9x10-3 per mg/kg-day |
| Ethyl Tertiary Butyl Ether (ETBE) | 637-92-3 | Inhalation |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Hepatocellular adenomas and carcinomas |
8x10-5 per mg/m3 |
| Ethylene oxide | 75-21-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Lymphoid cancer, (female) breast cancer |
3x10-3 per µg/m3 |
| Formaldehyde | 50-00-0 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Squamous cell carcinoma |
1.3x10-5 per µg/m3 |
| Furmecyclox | 60568-05-0 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Combined liver nodules and carcinomas |
3.0x10-2 per mg/kg-day |
| Heptachlor | 76-44-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
4.5 per mg/kg-day |
| Heptachlor | 76-44-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
1.3x10-3 per µg/m3 |
| Heptachlor epoxide | 1024-57-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
9.1 per mg/kg-day |
| Heptachlor epoxide | 1024-57-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
2.6x10-3 per µg/m3 |
| Hexachlorobenzene | 118-74-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma |
4.6x10-4 per µg/m3 |
| Hexachlorobenzene | 118-74-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma |
1.6 per mg/kg-day |
| Hexachlorobutadiene | 87-68-3 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Renal tubular adenomas and adenocarcinomas |
7.8x10-2 per mg/kg-day |
| Hexachlorobutadiene | 87-68-3 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Renal tubular adenomas and adenocarcinomas |
2.2x10-5 per µg/m3 |
| alpha-Hexachlorocyclohexane (alpha-HCH) | 319-84-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas |
1.8x10-3 per µg/m3 |
| alpha-Hexachlorocyclohexane (alpha-HCH) | 319-84-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas |
6.3 per mg/kg-day |
| beta-Hexachlorocyclohexane (beta-HCH) | 319-85-7 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas |
5.3x10-4 per µg/m3 |
| beta-Hexachlorocyclohexane (beta-HCH) | 319-85-7 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas |
1.8 per mg/kg-day |
| technical Hexachlorocyclohexane (t-HCH) | 608-73-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver nodules and hepatocellular carcinomas |
1.8 per mg/kg-day |
| technical Hexachlorocyclohexane (t-HCH) | 608-73-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver nodules and hepatocellular carcinomas |
5.1x10-4 per µg/m3 |
| Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD | 57653-85-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) |
6.2x103 per mg/kg-day |
| Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD | 57653-85-7 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) |
1.3 per µg/m3 |
| Hexachloroethane | 67-72-1 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Renal adenomas and carcinomas (combined) |
4x10-2 per mg/kg-day |
| Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) | 121-82-4 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) |
8x10-2 per mg/kg-day |
| Hydrazine/Hydrazine sulfate | 302-01-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatoma |
3.0 per mg/kg-day |
| Hydrazine/Hydrazine sulfate | 302-01-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity adenoma or adenocarcinoma |
4.9x10-3 per µg/m3 |
| Isophorone | 78-59-1 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Preputial gland carcinoma |
9.5x10-4 per mg/kg-day |
| Libby Amphibole Asbestos | 1318-09-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Cancer mortality from lung cancer and mesothelioma |
1.7x10-1 per fiber/cc |
| 4,4'-Methylene bis(N,N'-dimethyl)aniline | 101-61-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Thyroid, follicular cell carcinoma/ adenoma |
4.6x10-2 per mg/kg-day |
| Nickel refinery dust | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer |
2.4x10-4 per µg/m3 |
|
| Nickel subsulfide | 12035-72-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer |
4.8x10-4 per µg/m3 |
| Nitrobenzene | 98-95-3 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas |
4x10-5 per µg/m3 |
| N-Nitroso-N-methylethylamine | 10595-95-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
2.2x101 per mg/kg-day |
| N-Nitroso-di-n-butylamine | 924-16-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors |
1.6x10-3 per µg/m3 |
| N-Nitroso-di-n-butylamine | 924-16-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors |
5.4 per mg/kg-day |
| N-Nitrosodi-N-propylamine | 621-64-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas |
7.0 per mg/kg-day |
| N-Nitrosodiethanolamine | 1116-54-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma, cholangiocellular carcinoma and adenoma and neoplastic nodules |
2.8 per mg/kg-day |
| N-Nitrosodiethylamine | 55-18-5 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors |
1.5x102 per mg/kg-day |
| N-Nitrosodiethylamine | 55-18-5 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors |
4.3x10-2 per µg/m3 |
| N-Nitrosodimethylamine | 62-75-9 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors |
1.4x10-2 per µg/m3 |
| N-Nitrosodimethylamine | 62-75-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors |
5.1x101 per mg/kg-day |
| N-Nitrosodiphenylamine | 86-30-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Transitional cell carcinoma of the bladder |
4.9x10-3 per mg/kg-day |
| N-Nitrosopyrrolidine | 930-55-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma |
6.1x10-4 per µg/m3 |
| N-Nitrosopyrrolidine | 930-55-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma |
2.1 per mg/kg-day |
| Pentachlorophenol | 87-86-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas |
4x10-1 per mg/kg-day |
| Polychlorinated Biphenyls (PCBs) | 1336-36-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas |
1x10-4 per µg/m3 (Applies to inhalation of evaporated congeners) |
| Polychlorinated Biphenyls (PCBs) | 1336-36-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas |
2 per mg/kg-day |
| Prochloraz | 67747-09-5 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Liver adenoma/ carcinoma combined |
1.5x10-1 per mg/kg-day |
| Propylene oxide | 75-56-9 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity hemangioma or hemangiosarcoma |
3.7x10-6 per µg/m3 |
| Propylene oxide | 75-56-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Forestomach, squamous cell carcinoma |
2.4x10-1 per mg/kg-day |
| Quinoline | 91-22-5 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatic hemangioendotheliomas or hemangiosarcomas |
3 per mg/kg-day |
| 1,1,1,2-Tetrachloroethane | 630-20-6 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma |
7.4x10-6 per µg/m3 |
| 1,1,1,2-Tetrachloroethane | 630-20-6 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma |
2.6x10-2 per mg/kg-day |
| 1,1,2,2-Tetrachloroethane | 79-34-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
hepatocellular carcinomas |
2x10-1 per mg/kg-day |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas |
2.1x10-3 per mg/kg-day |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas |
0 |
| Toxaphene | 8001-35-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic nodules |
1.1 per mg/kg-day |
| Toxaphene | 8001-35-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic nodules |
3.2x10-4 per µg/m3 |
| Trichloroacetic acid | 76-03-9 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Hepatocellular adenomas or carcinomas |
7x10-2 per mg/kg-day |
| 1,1,2-Trichloroethane | 79-00-5 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular carcinoma |
1.6x10-5 per µg/m3 |
| 1,1,2-Trichloroethane | 79-00-5 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular carcinoma |
5.7x10-2 per mg/kg-day |
| Trichloroethylene | 79-01-6 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors |
4.1x10-6 per µg/m3 |
| Trichloroethylene | 79-01-6 | Oral |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors |
4.6 x10-2 per mg/kg-day |
| 2,4,6-Trichlorophenol | 88-06-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Leukemia |
3.1x10-6 per µg/m3 |
| 2,4,6-Trichlorophenol | 88-06-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Leukemia |
1.1x10-2 per mg/kg-day |
| 1,2,3-Trichloropropane | 96-18-4 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas |
3x101 per mg/kg-day |
| Trifluralin | 1582-09-8 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Combined renal pelvis carcinomas, urinary bladder papillomas and/or thyroid adenomas and carcinomas |
7.7x10-3 per mg/kg-day |
| 2,4,6-Trinitrotoluene (TNT) | 118-96-7 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Urinary bladder, transitional cell papilloma and transitional squamous cell carcinomas |
3.0x10-2 per mg/kg-day |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
8.8x10-6 per µg/m3 (Continuous lifetime exposure from birth) |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
4.4x10-6 per µg/m3 (Continuous lifetime exposure during adulthood) |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
1.5 per mg/kg-day (Continuous lifetime exposure from birth) |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
1.4 per mg/kg-day (Continuous lifetime exposure from birth) |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
7.5x10-1 per mg/kg-day (Continuous lifetime exposure during adulthood) |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
7.2x10-1 per mg/kg-day (Continuous lifetime exposure during adulthood) |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
8.8x10-6 per µg/m3 (Continuous lifetime exposure from birth) |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
4.4x10-6 per µg/m3 (Continuous lifetime exposure during adulthood) |
| tert-Butyl Alcohol (tBA) | 75-65-0 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Renal adenomas and carcinomas, thyroid adenomas |
5x10-4 per mg/kg-day |