STATISTICAL METHODS FOR ESTIMATING RISK FOR EXPOSURE ABOVE THE REFERENCE DOSE
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Abstract
A statistical method has been developed that provides a risk estimate for noncarcinogenic effects at a given dose. he method uses a categorical regression procedure to model severity of effect as it relates to experimental dose. oxicity data are analyzed from multiple animal experiments that span different species, target organs, toxic effects, and exposure conditions. he data are screened for homogeneity with respect to experiment duration and route of exposure. he resulting dose-response curve provides an estimate of the risk of adverse effects that may be useful in estimating risk for exposures above the reference dose (RfD).
Citation
U.S. EPA. STATISTICAL METHODS FOR ESTIMATING RISK FOR EXPOSURE ABOVE THE REFERENCE DOSE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-90/065.