Benchmark Dose Software (BMDS) Development and Maintenance Multitumor (MS _ Combo) Model
This document describes the technical background necessary to understand the assumptions and application of the BMDS MS_Combo program
The purpose of the MS_Combo program in BMDS is to allow the user to calculate BMDs and BMDLs for a combination of tumors (corresponding to a defined risk of getting one or more of those tumors) when the individual tumor dose-responses have been modeled using a Multistage-Cancer model. Thus, the output of an MS_Combo run will present the results of fitting each individual tumor (including the BMD and BMDL for that tumor) plus the combined log - likelihood, BMD, and BMDL for the combination of specified tumor responses.
The purpose of the MS_Combo program in BMDS is to allow the user to calculate BMDs and BMDLs for a combination of tumors (corresponding to a defined risk of getting one or more of those tumors) when the individual tumor dose-responses have been modeled using a Multistage-Cancer model. Thus, the output of an MS_Combo run will present the results of fitting each individual tumor (including the BMD and BMDL for that tumor) plus the combined log - likelihood, BMD, and BMDL for the combination of specified tumor responses.
Impact/Purpose
The purpose of the MS_Combo program in BMDS is to allow the user to calculate BMDs and BMDLs for a combination of tumors (corresponding to a defined risk of getting one or more of those tumors) when the individual tumor dose-responses have been modeled using a Multistage-Cancer model.
Citation
U.S. EPA. Benchmark Dose Software (BMDS) Development and Maintenance Multitumor (MS _ Combo) Model. U.S. Environmental Protection Agency, Washington, DC, 2012.
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
- Technical Background for MS _ Combo Program (PDF) (2 pp, 204 KB, about PDF)
Related Link(s)
- Benchmark Dose Software Development And Maintenance Ten Berge Cxt Models
- Benchmark Dose Software (BMDS) Development and Maintenance Toxicodiffusion Model (External Review Draft, Version 1.0)
- Peer Review Documents Related to the Evaluation of Benchmark Dose Software (BMDS) (External Review Draft, version 1.1b)
- Peer Review of EPA's Draft BMDS Document: Exponential Continuous Models (External Review Draft, Version 1.1)
- Choosing Appropriate Stage of a Multistage Model for Cancer Modeling (BMDS Technical Guidance)