APPLICATIONS OF AN EXACT NOAEL PROCEDURE FOR DICHOTOMOUS DATA FROM ANIMAL EXPERIMENTS
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
A statistical method has been developed that utilizes a step-wise hypothesis testing procedure to estimate the distribution of the no-observed-adverse-effect level (N0AEL), and thereby to estimate the expected value of the NOAEL and its variability. The methodology is dependent upon the sum of the dose group sizes, the expected response rates, experimental dose levels, and the type I error rates. The technique may be employed to evaluate the reliability of the NOAEL and to provide a measure of its variability.
Citation
U.S. EPA. APPLICATIONS OF AN EXACT NOAEL PROCEDURE FOR DICHOTOMOUS DATA FROM ANIMAL EXPERIMENTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-89/068.
Additional Information
Project Officer Jeff Swartout, FTS 684-7811