IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)
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Abstract
Trimethylbenzenes (TMB) are a mixture of three isomers: 1,2,3-, 1,2,4- and 1,3,5-TMB. TMBs are produced during petroleum refining, and 1,2,4-TMB makes up approximately 40% of a certain petroleum product (the C9 fraction) which is used as a component of gasoline. Because of this, vehicle emissions are a major source of TMBs. Other uses of TMBs include solvents in research and industry, dyestuff intermediate, paint thinner, and as a UV oxidation stabilizer for plastics.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Feb 2012 | EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Trimethylbenzenes. |
May 2012 | EPA sent an abbreviated version of the toxicological review containing only information on 1,2,3-trimethylbenzene for Interagency Science Consultation at the recommendation of reviewers. |
Jun 2012 | EPA released the external peer review draft of the trimethylbenzenes assessment for public review and comment. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft), Jan 2012 (PDF) (95 pp, 1 MB, about PDF)
- Draft Charge to External Peer Reviewers (Interagency Science Consultation Draft) Jan 2012 (PDF) (5 pp, 45 KB, about PDF)
- EPA's Response and Comments from the Interagency Science Consultation (PDF) (10 pp, 247 KB, about PDF)
- 1. CDC ATSDR Comments on the TMB IASC (PDF) (2 pp, 29 KB, about PDF)
- 2. CEQ Comments on the TMB IASC (PDF) (1 pp, 48 KB, about PDF)
- 3. DoD DUSD ( I&E ) Comments on the TMB IASC (PDF) (26 pp, 181 KB, about PDF)
- 4. NIEHS NTP Comments on the TMB IASC (PDF) (1 pp, 38 KB, about PDF)
- 5. NIOSH Comments on the TMB IASC (PDF) (1 pp, 24 KB, about PDF)
- Dose-response Analysis of 1,2,3-Trimethylbenzene (Interagency Science Consultation Draft), May 2012 (PDF) (19 pp, 683 KB, about PDF)
- Supplemental Information of 1,2,3-Trimethylbenzene (Interagency Science Consultation Draft), May 2012 (PDF) (13 pp, 720 KB, about PDF)
- Draft Charge Questions for 1,2,3-Trimethylbenzene, May 2012 (PDF) (1 pp, 59 KB, about PDF)
- 1. CEQ Comments on 1,2,3-TMB (PDF) (1 pp, 35 KB, about PDF)
- 2. DOD DUSD ( I&E ) Comments on 1,2,3-TMB (PDF) (2 pp, 26 KB, about PDF)
- 3. NIEHS NTP Comments on 1,2,3-TMB (PDF) (1 pp, 139 KB, about PDF)